Largest Series A Funding Rounds in History | Eqvista

Last Updated: Feb 202 6

There is no quick or easy way to get equity capital for a business. If you’re successful, however, you’ll have the means to see your business through to its full potential. Series A fundraising rounds are very important to a startup’s development and eventual success. The Series A funding rounds follow a company’s first seed investment and are often seen as a reliable indicator of the company’s future success. Startups often utilize Series A funding to begin implementing their go-to-market strategy, which often includes making a large number of new hires. It is also a vital step for investors who are seeking lucrative stock shares in firms that will be the market leaders of the future. To accomplish all of these, you must have a comprehensive idea about the money involved in series A funding and some of the largest series A funding rounds in history. In this article, we will examine a few of the most noteworthy fundraising achievements in recent years.

Series A funding rounds

If a firm has made it past the seed stage but is also showing signs of growth in terms of users, income, or views, it may decide to secure Series A round funding to assist propel them to a higher level. Although a proven business model may not be required for Series A funding, a firm should have a strategy for creating one. They must utilize the funds to boost sales as well. Let’s understand Series A funding rounds better.

What is series A funding?

Funding for a company sometimes includes a financing round known as series A financing (or simply series A funding). In its most basic form, the series A round serves both as the second step of the startup financing process and the first stage of the venture capital financing process. A startup at this point has a proven track record but is still relatively new, meaning its most successful years are ahead of it. Venture capitalists tend to have better success with firms in the Series A financing round than with those in later stages of development.

Series A funding is also an equity-based financing option, like seed funding. To raise money, businesses often offer shares to the public for purchase. In most situations, however, anti-dilution clauses are included in series A financing. In most cases, preferred shares are distributed by startups, and the owners of these shares do not get voting rights.

How does series A funding work?

Series A funding rounds are far more formal than seed money stages. The bulk of this fundraising round’s investors are venture capitalists, and they are ready to wait for the company to finish the verification and valuation procedures before deciding whether or not to participate. So, these procedures kick off any significant series A financing.

The United States had the largest increase ( 125%) in Series A financing of any major area in 2021. By 2022, however, the United States market had pulled back even farther, by 33 per cent, compared to the rest of the world.

The success of a company’s management and the return on its initial investment are both factors that must be considered throughout a fundraising campaign. A company’s ability to generate future earnings is also reflected in its value, showing how effectively management has planned for the company’s growth. Venture capitalists won’t put money into a firm until after it’s been thoroughly investigated and valued.

Money involved in Series A funding

Series A financing usually ranges between $2 million and $15 million, much more than the seed round’s $1 million. Hence, before committing to a series A investment round, investors will expect more substance than was necessary for the seed round. It also implies fewer overall contributions are made during series A financing rounds due to the larger bite size. This pattern persists through subsequent financing rounds, from A to B and beyond. In general, fewer checkwriters are available to finance a larger round.

It’s also not enough to just have a fantastic concept; today’s entrepreneurs must provide concrete evidence that their venture will be successful. For series A fundraising rounds, a company’s value is typically between $10 million and $15 million.

Benefits of Series A funding

The following is a list of the benefits of Series A funding rounds for your better understanding:

Structure of Series A funding

Due investigation and analysis from institutional investors, as well as the legal fees and costs incurred by the firm to accommodate new investors, make smaller investments less attractive. Seeking angel investment is common practice for startups in need of operating finance but not yet prepared to attract venture financing. Given the price of doing business in industries like software development, data services, telecommunications, etc., larger sums are often unnecessary. Yet, it’s not uncommon for series A funding rounds to exceed $10 million in industries like biotech, electronics, and real estate. Although the fundamental legal and financial structures are the same, the particular terminology, contract terms, and investing practices of each country, industry, and group of investors are unique.

Preferred stocks of Series A represent the initial offering of equity by a portfolio business to a venture capital investor in the United States, often at the seed or initial stage round. IPOs and firm sales commonly convert Series A preferred shares into common stock.

There is extensive coverage of Series A financing rounds in blogs, industry publications, business press, and other sources that focus on the technology sector in the United States, especially in Silicon Valley. Series A funding rounds in non-tech sectors also attract capital from institutional investors like banks and corporations as well as individual investors like wealthy individuals and charitable organizations, although they are seldom covered by the media like those in the tech sector.

Sources of capital in series A funding

Due to the lack of a public marketplace for their assets, private companies connect with VC firms and investors in private equity through a variety of channels, such as warm introductions from the investors’ existing network of trusted sources and business contacts, investor conferences, and demo days. Companies in the United States are increasingly turning to online marketplaces to raise their Series A round of capital as equity crowdfunding evolves. Together with traditional VC firms, these mixed rounds often include angel, strategic, and capital investors.

Series A funding trends

The average Series A funding round in 2013 was $6 million, with the median being $3 million. The average Series A financing round this year is approximately $20 million, with the median round size being over $10 million. Around $14 million was raised in a typical Series A round in 2020, with $7.5 million being the median.

Global Series A financing increased by almost 100% in 2021 but then dropped by 23% the following year. While Series A funding was down, it wasn’t as bad as Series B and afterwards. Annual declines in financing for series B rounds have been 30%, while for series C and subsequent rounds, the reduction has been 45% in 2022 compared to the previous year.

Nevertheless, entrepreneurs can’t simply stop raising money after the Series A funding round. There is still the rest of the alphabet to go. The prognosis for startups raising at the Series A level in 2022 has not diminished much relative to the magnitude of funding. Nevertheless, given the decline in financing beyond Series A, startups may get trapped until Series B and beyond funding increase in the second half of 2023.

According to Crunchbase, in 2021, more than 5,000 firms received a total of $90 billion in Series A investment, a record high. As of December 11th, only approximately 4,000 firms had received $70 billion in Series A capital this year.

Largest Series A Funding from Feb 2016 – 2026 (Based in US)

While higher sums of money are often raised in subsequent investment rounds, the Series A phase is nevertheless crucial for developing businesses. An analysis of Series A financing finds regional differences as well. Let’s take a closer look at the largest series A funding rounds in history.

S. No. Organization Name Funding Amount (in USD) Funding Year
1 Altos Labs $3.0B 2021
2 Articulate $1.5B 2021
3 Xaira Therapeutics $1.0B 2024
4 Pacific Fusion $900.0M 2024
5 Perch $775.0M 2021
6 Transmit Security $543.0M 2021
7 Tempo $500.0M 2025
8 FTX US $400.0M 2022
9 Candid Therapeutics $370.0M 2024
10 Benitago Group $325.0M 2021
11 Field AI $314.0M 2025
12 Ricursive Intelligence $300.0M 2026
13 Uniquity Bio $300.0M 2024
14 ReNAgade Therapeutics $300.0M 2023
15 Orbital Therapeutics $270.0M 2023
16 Liquid AI $250.0M 2024
17 Rivos $250.0M 2024
18 Anthos Therapeutics $250.0M 2019
19 Partager $250.0M 2023
20 Bungalo $250.0M 2018
21 Aiolos Bio $245.0M 2023
22 Dispatch Bio $216.0M 2025
23 Tome Biosciences $213.0M 2023
24 Crystalys Therapeutics $205.0M 2025
25 Upscale AI $200.0M 2026
26 AirNexis Therapeutics $200.0M 2026
27 Treeline Biosciences $200.0M 2025
28 Soufflé Therapeutics $200.0M 2025
29 ProbablyMonsters $200.0M 2021
30 Tenvie Therapeutics $200.0M 2025
31 Callio Therapeutics $187.0M 2025
32 Braveheart Bio $185.0M 2025
33 Muck Rack $180.0M 2022
34 Timberlyne Therapeutics $180.0M 2025
35 Antares Therapeutics $177.0M 2025
36 Expedition Therapeutics $165.0M 2025
37 Third Arc Bio $165.0M 2024
38 Alveus Therapeutics $160.0M 2026
39 Moonshot Brands $160.0M 2021
40 GentiBio $157.0M 2021
41 LMArena $150.0M 2026
42 Character.ai $150.0M 2023
43 Farcaster $150.0M 2024
44 Vast $150.0M 2025
45 Conductor $150.0M 2021
46 MasterControl $150.0M 2022
47 Clasp Therapeutics $150.0M 2024
48 Opto Investments $145.0M 2022
49 Bitterroot Bio $145.0M 2023
50 Standard Nuclear $140.0M 2026
51 FGI Finance $140.0M 2017
52 EasyHealth $135.0M 2021
53 City Therapeutics $135.0M 2024
54 SaveLive $135.0M 2021
55 7AI $130.0M 2025
56 Cavnue $130.0M 2022
57 Jasper $125.0M 2022
58 Ambros Therapeutics $125.0M 2025
59 iTrustCapital Inc. $125.0M 2022
60 D1 Brands $123.0M 2021
61 NS8 $123.0M 2020
62 NGM Biopharmaceuticals $122.0M 2024
63 Merida Biosciences $121.0M 2025
64 Dyna Robotics $120.0M 2025
65 Solve Therapeutics $120.0M 2025
66 Ouro Medicines $120.0M 2025
67 Cellular Biomedicine Group $120.0M 2021
68 Axonis Therapeutics $115.0M 2024
69 Author Health $115.0M 2023
70 Syncromune $111.8M 2024
71 Zephyr AI $111.0M 2024
72 Neurophos $110.0M 2026
73 Zarminali Health $110.0M 2026
74 Nexthop AI $110.0M 2025
75 Masterworks $110.0M 2021
76 RayThera $110.0M 2025
77 Neomorph $109.0M 2020
78 Corgi Insurance $108.0M 2026
79 AavantiBio $107.0M 2020
80 Valar Atomics $105.0M 2025
81 Eudia $105.0M 2025
82 Antithesis $105.0M 2025
83 Luminous Computing $105.0M 2022
84 Cour Pharmaceuticals Development $105.0M 2024
85 3D VIRTUAL TECHNOLOGIES, LLC $105.0M 2022
86 Synnovation Therapeutics $102.0M 2023
87 NILO Therapeutics $101.0M 2025
88 Trace Neuroscience $101.0M 2024
89 DevRev $100.8M 2024
90 Parallel $100.0M 2025
91 DoiT $100.0M 2019
92 Lower $100.0M 2021
93 Addition Therapeutics $100.0M 2025
94 TensorWave $100.0M 2025
95 1047 Games $100.0M 2021
96 Place $100.0M 2021
97 Auger $100.0M 2024
98 Dyno Therapeutics $100.0M 2021
99 Scorpion $100.0M 2021
100 Zyphra $100.0M 2025
101 LoanPro $100.0M 2021
102 Lumeris $100.0M 2024
103 MatX $100.0M 2024
104 Climavision $100.0M 2021
105 Nudge $100.0M 2025
106 Substrate $100.0M 2025
107 Ollin Biosciences $100.0M 2025
108 Xcimer Energy $100.0M 2024
109 Inceptive $100.0M 2023
110 Rectify Pharmaceuticals $100.0M 2021
111 Navigator Medicines $100.0M 2024
112 OnCusp Therapeutics $100.0M 2024
113 Bubble $100.0M 2021
114 Faze $100.0M 2022
115 CoinTracker $100.0M 2022
116 Paratus Sciences $100.0M 2023
117 Joyn Bio $100.0M 2017
118 Advise Insurance $100.0M 2021
119 Miracle Miles tech $100.0M 2022
120 Brandbadge $100.0M 2021
121 Bluestar Energy Capital $99.8M 2022
122 Cajal Neuroscience $96.0M 2022
123 Firefly Bio $94.0M 2024
124 Newleos Therapeutics $93.5M 2025
125 Bonum Therapeutics $93.0M 2022
126 RocketReach.co $92.0M 2020
127 Kivu Bioscience $92.0M 2024
128 DualEntry $90.0M 2025
129 Rentberry $90.0M 2024
130 Majestic Labs ai $90.0M 2025
131 Halborn $90.0M 2022
132 Nested Therapeutics $90.0M 2022
133 Industrial Sun $90.0M 2023
134 Clade Therapeutics $87.0M 2021
135 Augment $85.0M 2025
136 HavocAI $85.0M 2025
137 Stylus Medicine $85.0M 2025
138 Rampart Bioscience $85.0M 2023
139 Epirium Bio $85.0M 2019
140 Bioleum $85.0M 2025
141 CITRÖN VENTURES $85.0M 2019
142 Moon Valley Software $84.0M 2025
143 Satellite Bio $82.5M 2022
144 Mendra $82.0M 2026
145 Exsilio Therapeutics $82.0M 2024
146 Tisento Therapeutics $81.0M 2023
147 Faze Medicines $81.0M 2020
148 Higgsfield $80.0M 2026
149 Corsera Health $80.0M 2026
150 Parry Labs $80.0M 2024

Data Source: Crunchbase